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By Joseph C. Arcos, Yin-Tak Woo, Mary F. Argus

Chemical Induction of melanoma: Structural Bases and organic Mechanisms quantity IIIA bargains with the natural and biochemical rules at the back of cancer.

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Extra resources for Aliphatic Carcinogens. Structural Bases and Biological Mechanisms

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The carcinogenic activity of chloroalkyl ethers decreases as chlorine moves further away from the ether oxygen. , bis(a-chloroethyl) ether]. 3. The carcinogenic activity decreases as the alkyl chain length increases. For example, if one considers bis(chloromethyl) ether, bis-l,2-(chloromethoxy)ethane, bis-l,4-(chloromethoxy)butane, and bis-1,6-(chloromethoxy)hexane as a homologous series of di-a-chloro ethers of increasing length, it is clear that in general the longer the chain length, the lower the carcinogenicity.

41 m l / k g = 435 m g / k g LDB L D ^ = 3000 m g / k g (99) (102) (99) (101) (101) (100) = 240 m g / k g (100) 75 m g / k g '(99) = 300 m g / k g = 0 . 3 ppm for 6 hr = 7 p p m for 7 hr R a t ( i . 1 Carcinogenic Cross-Unking Agents and Alkyl Donors The mutagenicity of haloethers has been investigated in bacterial (108-110) and in eukaryotic and mammalian systems (111). Table XIV summarizes the microbial mutagenicity of a variety of haloethers in comparison to their carcinogenicity. There is a reasonably good qualitative correlation between mutagenicity and carcinogenicity.

Shimkin, J . H . Weisburger, E. K. Weisburger, N. Gubareff, and V. Suntzeff. [J. Nati. Cancer Inst. 36, 915 (1966)]. The mice used were of the strain A / J . c Summarized from G. D. Stoner, M. B. Shimkin, A . J . Kniazeff, J . H . Weisburger, E. K. Weisburger, and G. Gori [Cancer Res. 33, 3069(1973)]. c. injections to rats and mice. In both species, the induction of local sarcomas by each of the four compounds was observed. In the rat, ß-naphthylamine mustard was the most potent compound, inducing tumors in 100% of the rats with a latent period of 8 months.

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