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01 as compared with normal at the same time (one-way ANOVA followed by Dunnett’s multiple comparison test) activity with increase in dose. w. 6). 7 Effect of Extracts of Artemisia amygdalina and Glibenclamide on Various Biochemical Parameters in Rats The extracts of A. 7). Total protein was found to be lowered in diabetic control group, while it was found to be elevated in the extract- and glibenclamidetreated diabetic rats. 8. , polyphagia and polydipsia. The extract- and glibenclamide-treated rats consumed less water and feed when compared with the diabetic control ones.
2008; Ruikar et al. 2011; Efferth 2007; Wong and Brown 2002). This chapter unfolds the secondary metabolite constitution of this plant with regard to isolation, characterisation, cytotoxicity evaluation, and chemobiological standardization of Artemisia amygdalina. This chapter therefore envisages contributing towards: (i) The integrated assessment of the chemical composition and exploitation potential of A. amygdalina Decne. (ii) The biological potential of the isolated chemical constituents from A.
As a result isolation of the active principles responsible for such effect has been carried out and the isolates assayed for their cytotoxicity profile using SRB assay. 1, it is clear that except compound 1, all others exhibited greater than 50 % inhibition at the tested concentration, so they were further screened to determine IC50 values. Almost the compounds displayed cytotoxity against all the four tested cancer cell lines. 9 µM respectively. 9 µM. 2). 2 Cytotoxicity of the isolates against human dermal fibroblasts (CRL1635) by MTT assay Compound 1 2 3 4 5 6 Conc.